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    Welcome to

Josep Sardanyés  Cayuela (Ph.D.)

       website





Scientists are perennially aware that it is best not to trust theory until it is confirmed by evidence. It is equally true... that it is best not to put too much faith in facts until they have been confirmed by theory.
                                                                                                  Robert McArthur




CURRENT RESEARCH

I am currently doing my second postdoc at Gladstone Institute of Virology and Immunology at University of California San Francisco (UCSF). I have joined Leor Weinberger's lab and my research is concerned with the dynamics of viruses such as herpesviruses, HIV-­1 and HCV. I am interested in the transcriptional regulation and the role of stochasticity in the gene expression of these pathogens, as well as in their within­-cell dynamics. I adress these subjects using mathematical modeling, nonlinear dynamical systems and computational biology.


PAST RESEARCH

From September 2009 to May 2011 I did a postdoc at the Evolutionary Systems Virology Group at the Universitat Politècnica de València (UPV-CSIC), working with Prof. Santiago F. Elena on plant RNA viruses. From June 2004 to May 2009 I did a Ph.D. thesis at Universitat Pompeu Fabra working in the Complex Systems Lab, placed at the Barcelona Biomedical Research Park (PRBB). My PhD supervisor was Ricard V. Solé.

I have worked in the PACE project (Programmable Artificial Cell Evolution) in the period 2004-2008 and in a project funded by the Human Frontier Science Program Organization studying the evolutionary implications of virus-encoded gene silencing suppression.


SUMMARY OF SCIENTIFIC INTERESTS

My scientific interests span several fields of theoretical biology and complex systems. I am currently doing theoretical and computational research on human viruses in close collaboration with experimentalists. I am also doing research on quasispecies theory applied to RNA viruses dynamics and evolution. Specially during my Ph.D. I also studied the hypercycle theory related to the origin of life problem. In the field of virology I have been working with RNA silencing pathways and plant RNA virus dynamics and evolution. I use tools from nonlinear dynamical systems theory to study the dynamics, the bifurcations and the transitions in biological systems. I am also doing theoretical research on tumour growth models, epidemiology, immunology and theoretical ecology. I am also interested in control theory and chaos.


My latest publication: Sardanyés J.*, Martínez F., Daròs J. A., and Elena, S. F., Dynamics of alternative modes of RNA replication for positive­sense RNA viruses. J. Roy. Soc. Interface (2011). In Press.